Parallel Synthesis of Aurones Using a Homogeneous Scavenger

The ability to synthesize arrays of related compounds quickly and with good purity has become critical for a rapid exploration their properties biological or material applications. While number methods have been developed enable this combinatorial synthesis, the existing options were not readily appliable synthesis aurones using simple Knoevenagel condensation approach. In order avoid time, expense, lowered yields associated flash column chromatography, we scavenging approach synthesis. This method uses an excess aldehyde ensure complete conversion aurones, followed by selective removal remaining simple, inexpensive scavenger – isoniazid subsequent extraction dilute acid, produce desired under operationally conditions. is expected be applicable many other reactions involving aldehydes as one reactants.